Which uricosuric agent is commonly used as uricosuric therapy in chronic gout?

• A. Probenecid
• B. Allopurinol
• C. Febuxostat
• D. Pegloticase

Answer: (A)

Uricosuric therapy lowers uric acid by increasing its excretion in the urine. Probenecid is the classic uricosuric agent that works by blocking the renal reabsorption of urate in the proximal tubule, thereby boosting urinary uric acid elimination. This makes it a common choice for chronic gout when the main issue is underexcretion of uric acid. The other options work differently: allopurinol and febuxostat reduce uric acid production by inhibiting xanthine oxidase, not excretion; pegloticase is a enzyme that breaks down uric acid and is used for severe, refractory gout. Therefore, probenecid best fits the uricosuric therapy approach in chronic gout.