Which tissue is primarily affected in Dupuytren contracture?

• A. Palmar fascia
• B. Extensor tendon
• C. Synovial membrane of joints
• D. Interosseous membrane

Answer: (A)

Dupuytren contracture is a fibromatosis of the palmar fascia, specifically the palmar aponeurosis. The palmar fascia thickens and forms nodules and cords that shorten, pulling on the finger flexors to produce contractures, usually of the ring and little fingers. Because the disease targets the palmar fascia, that tissue is the primary one affected. Structures like the extensor tendons on the back of the hand, the synovial membranes lining joints, or the interosseous membranes between forearm bones are not the main sites of disease, so they aren’t responsible for the functional problem seen in this condition.