Which statement is true about allopurinol and febuxostat?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Which statement is true about allopurinol and febuxostat?

Explanation:
The central idea is that both drugs inhibit xanthine oxidase, the enzyme responsible for converting hypoxanthine to xanthine and then xanthine to uric acid. By blocking this step, they reduce uric acid production and help prevent urate crystal deposition in chronic gout. They do not increase uric acid excretion (that would be uricosuric agents), they are not enzymes that break down uric acid (uricases), and they are not NSAIDs. So the statement that they are xanthine oxidase inhibitors used for chronic gout is the true one.

The central idea is that both drugs inhibit xanthine oxidase, the enzyme responsible for converting hypoxanthine to xanthine and then xanthine to uric acid. By blocking this step, they reduce uric acid production and help prevent urate crystal deposition in chronic gout. They do not increase uric acid excretion (that would be uricosuric agents), they are not enzymes that break down uric acid (uricases), and they are not NSAIDs. So the statement that they are xanthine oxidase inhibitors used for chronic gout is the true one.

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