Which of the following is NOT listed among first-line CRPS treatments?

• A. Analgesics/NSAIDs
• B. Amitriptyline
• C. Gabapentin
• D. Corticosteroids

Answer: (D)

CRPS treatment aims to relieve pain and preserve function using options with solid short- and long-term benefit and acceptable safety. The first-line approach typically includes NSAIDs and other analgesics for general pain, along with neuropathic-pain modulators like amitriptyline and gabapentin to address the nerve-related pain that often accompanies CRPS. Corticosteroids are not generally listed among first-line treatments because the evidence for sustained benefit is inconsistent and their use carries risks such as glucose intolerance, osteoporosis, and immunosuppression with longer courses. They may be considered in select patients with an acute inflammatory presentation for a short trial under careful supervision, but they are not part of the standard initial regimen.