Which of the following is a B cell modulator?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Which of the following is a B cell modulator?

Explanation:
B cell modulators work by directly reducing B cell numbers or their activity, which decreases antibody production and alters antigen presentation. Rituximab fits this by targeting CD20 on B cells and depleting them through immune mechanisms like ADCC and CDC. This direct B cell depletion dampens B cell–driven immune responses. Abatacept, by contrast, blocks the CD28–CD80/86 costimulatory signal needed for T cell activation, so it mainly modulates T cell responses rather than B cells. Tocilizumab inhibits the IL-6 receptor to reduce inflammatory signaling, and Anakinra blocks the IL-1 receptor; neither directly targets B cells.

B cell modulators work by directly reducing B cell numbers or their activity, which decreases antibody production and alters antigen presentation. Rituximab fits this by targeting CD20 on B cells and depleting them through immune mechanisms like ADCC and CDC. This direct B cell depletion dampens B cell–driven immune responses.

Abatacept, by contrast, blocks the CD28–CD80/86 costimulatory signal needed for T cell activation, so it mainly modulates T cell responses rather than B cells. Tocilizumab inhibits the IL-6 receptor to reduce inflammatory signaling, and Anakinra blocks the IL-1 receptor; neither directly targets B cells.

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