Which immunoglobulin rises in allergic disease states?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Which immunoglobulin rises in allergic disease states?

Explanation:
Allergic diseases are driven by an IgE-mediated response. B cells switch to producing IgE under the influence of Th2 cytokines like IL-4. The IgE then binds to FcεRI receptors on mast cells and basophils, sensitize them, and on re-exposure to the allergen cross-links the bound IgE, triggering degranulation and release of histamine, leukotrienes, and other mediators that cause the symptoms of allergy. This rise in IgE is the characteristic feature of allergic states, while the other immunoglobulins (IgG, IgA, IgD) are not specifically elevated in this context.

Allergic diseases are driven by an IgE-mediated response. B cells switch to producing IgE under the influence of Th2 cytokines like IL-4. The IgE then binds to FcεRI receptors on mast cells and basophils, sensitize them, and on re-exposure to the allergen cross-links the bound IgE, triggering degranulation and release of histamine, leukotrienes, and other mediators that cause the symptoms of allergy. This rise in IgE is the characteristic feature of allergic states, while the other immunoglobulins (IgG, IgA, IgD) are not specifically elevated in this context.

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