Which genetic factors are involved in rheumatoid arthritis?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Which genetic factors are involved in rheumatoid arthritis?

Explanation:
Genetic predisposition to rheumatoid arthritis is tightly linked to the MHC region, especially the HLA class II molecules. The HLA-DRB1 gene encodes part of the DRβ1 molecule, and certain DRB1 alleles, notably those in the DR4 serotype (historically called DRw4), carry a shared epitope that raises susceptibility and is often associated with more severe disease. Because DRB1 is within the MHC region, the genetic risk involves both the broad MHC locus and the specific HLA-DRB1/DRw4 alleles. While other non-MHC genes also contribute, these together capture the strongest genetic association seen in rheumatoid arthritis.

Genetic predisposition to rheumatoid arthritis is tightly linked to the MHC region, especially the HLA class II molecules. The HLA-DRB1 gene encodes part of the DRβ1 molecule, and certain DRB1 alleles, notably those in the DR4 serotype (historically called DRw4), carry a shared epitope that raises susceptibility and is often associated with more severe disease. Because DRB1 is within the MHC region, the genetic risk involves both the broad MHC locus and the specific HLA-DRB1/DRw4 alleles. While other non-MHC genes also contribute, these together capture the strongest genetic association seen in rheumatoid arthritis.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy