Which extra-articular manifestation is commonly associated with Ankylosing Spondylitis?

• A. Reiter's syndrome
• B. IBD
• C. Uveitis
• D. Psoriasis rash

Answer: (C)

Uveitis is a common extra-articular manifestation of Ankylosing Spondylitis. Ankylosing Spondylitis is a seronegative spondyloarthropathy often associated with HLA-B27, and besides spine and sacroiliac joint inflammation, it frequently involves other organ systems. The eye tends to be affected most often with acute anterior uveitis (iritis), presenting with redness, eye pain, photophobia, and decreased vision. It can flare independently of joint symptoms and requires prompt ophthalmologic evaluation. Treatment typically involves topical corticosteroids and cycloplegic drops, while controlling the underlying inflammatory disease can help reduce recurrence.

Reiter’s syndrome (reactive arthritis) is another member of the seronegative spondyloarthropathy family but is a distinct condition, not a direct extra-articular manifestation of Ankylosing Spondylitis. IBD and psoriasis can be associated with spondyloarthropathies, including AS, but uveitis is the most classic and commonly remembered ocular manifestation.