Which agent is an IL-1 receptor antagonist?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Which agent is an IL-1 receptor antagonist?

Explanation:
Blocking IL-1 signaling is the key idea. Anakinra is a recombinant IL-1 receptor antagonist that binds to the IL-1 receptor, preventing IL-1 alpha and IL-1 beta from signaling and thus reducing inflammation. This distinguishes it from the others: Tocilizumab blocks the IL-6 receptor, Rituximab depletes CD20+ B cells, and Abatacept interferes with T cell activation by inhibiting CD28 costimulation. Therefore, the agent that acts as an IL-1 receptor antagonist is Anakinra.

Blocking IL-1 signaling is the key idea. Anakinra is a recombinant IL-1 receptor antagonist that binds to the IL-1 receptor, preventing IL-1 alpha and IL-1 beta from signaling and thus reducing inflammation. This distinguishes it from the others: Tocilizumab blocks the IL-6 receptor, Rituximab depletes CD20+ B cells, and Abatacept interferes with T cell activation by inhibiting CD28 costimulation. Therefore, the agent that acts as an IL-1 receptor antagonist is Anakinra.

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