What term describes the chronic fatigue state lasting at least six months with cognitive difficulties?

• A. Myalgic encephalomyelitis (Chronic Fatigue Syndrome)
• B. Fibromyalgia
• C. Rheumatoid arthritis
• D. Sjögren syndrome

Answer: (A)

Myalgic encephalomyelitis, also known as chronic fatigue syndrome, is characterized by profound fatigue lasting at least six months that is not substantially improved by rest and is accompanied by cognitive difficulties such as memory problems and trouble concentrating (often described as brain fog). Many patients experience post-exertional malaise, where physical or mental activity worsens symptoms. This specific combination—long-lasting fatigue plus cognitive impairment—best fits ME/CFS.

Fibromyalgia involves widespread pain and fatigue but centers on pain symptoms and tender points. Rheumatoid arthritis is defined by inflammatory joint disease with stiffness and systemic inflammation. Sjögren syndrome features dry eyes and mouth with autoimmune features.