What is the primary target tissue in the pathogenesis of rheumatoid arthritis?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

What is the primary target tissue in the pathogenesis of rheumatoid arthritis?

Explanation:
Rheumatoid arthritis is driven by autoimmune inflammation that begins in the joint’s lining, the synovial membrane. The primary target tissue is the synovium, which becomes inflamed (synovitis) and proliferates to form pannus. This abnormal synovial tissue aggressively invades and erodes adjacent cartilage and subchondral bone, driven by inflammatory cells and cytokines that stimulate enzymes like matrix metalloproteinases. Cartilage and bone damage occur as a consequence of this synovial-driven destruction, rather than as the initial target. Tendons can be involved later, but the initiating pathology is synovial inflammation.

Rheumatoid arthritis is driven by autoimmune inflammation that begins in the joint’s lining, the synovial membrane. The primary target tissue is the synovium, which becomes inflamed (synovitis) and proliferates to form pannus. This abnormal synovial tissue aggressively invades and erodes adjacent cartilage and subchondral bone, driven by inflammatory cells and cytokines that stimulate enzymes like matrix metalloproteinases. Cartilage and bone damage occur as a consequence of this synovial-driven destruction, rather than as the initial target. Tendons can be involved later, but the initiating pathology is synovial inflammation.

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