What is the first-line pharmacologic therapy for fibromyalgia according to the material?

• A. Venlafaxine
• B. Pregabalin
• C. Amitriptyline
• D. Cyclobenzaprine

Answer: (D)

Fibromyalgia’s most burdensome symptoms often include sleep disturbance and widespread muscle pain, so the material emphasizes an approach that quickly improves sleep and reduces muscle tension. Cyclobenzaprine, a muscle relaxant with sedative effects, addresses these key symptoms directly by easing muscle spasms and promoting better sleep. Because improving sleep can lessen overall pain perception and daytime fatigue, cyclobenzaprine is presented as the first-line pharmacologic option. The other medications listed—venlafaxine, amitriptyline, and pregabalin—are valuable for many patients but are treated as alternatives or later steps in this material, often due to their broader side-effect profiles or the emphasis on rapid sleep-focused relief that cyclobenzaprine provides.