Rheumatoid factor measures agglutination between which immunoglobulins?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Rheumatoid factor measures agglutination between which immunoglobulins?

Explanation:
Rheumatoid factor is an IgM autoantibody that targets the Fc region of IgG. In a typical RF test, IgM RF in the patient’s serum binds to IgG (often coating the test particles), cross-linking IgG molecules and causing agglutination. This means the interaction being detected is between IgM (the RF antibody) and IgG (the target IgG). The other pairings don’t reflect the usual RF mechanism, which is why the correct interaction is IgM with IgG.

Rheumatoid factor is an IgM autoantibody that targets the Fc region of IgG. In a typical RF test, IgM RF in the patient’s serum binds to IgG (often coating the test particles), cross-linking IgG molecules and causing agglutination. This means the interaction being detected is between IgM (the RF antibody) and IgG (the target IgG). The other pairings don’t reflect the usual RF mechanism, which is why the correct interaction is IgM with IgG.

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