Parvovirus B19 infection in children is commonly associated with which rash description?

• A. Slapped cheeks
• B. Measles rash
• C. Fifth disease rash
• D. Urticaria

Answer: (D)

Parvovirus B19 infection in children classically presents with erythema infectiosum, known as Fifth disease. The hallmark rash is bright red cheeks that look as if they've been slapped, often followed by a lacy, reticular rash on the trunk and limbs. This description—slapped cheeks—along with the name Fifth disease, is the best way to recognize the rash associated with this infection. Urticaria describes hives, which isn’t the typical presentation for Parvovirus B19. Measles rash comes from a different infection and has a different pattern and accompanying symptoms (fever, cough, coryza, conjunctivitis, and Koplik spots). So the classic association is Fifth disease rash, with the characteristic slapped-cheek appearance.