Paget's disease is characterized by which pattern of bone turnover and remodeling?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Paget's disease is characterized by which pattern of bone turnover and remodeling?

Explanation:
Paget's disease shows a high bone turnover with a sequence of events: osteoclasts resorb bone aggressively, and then osteoblasts lay down new bone rapidly. However, the remodeling is disorganized, producing a mosaic of woven and lamellar bone rather than a regular, well-ordered structure. This combination—excessive resorption followed by excessive, abnormal formation—gives bones that are enlarged and structurally weak. This pattern is distinctive from simple osteoporosis (loss of bone mass), osteoarthritis (degenerative joint changes), or rheumatoid-arthritis–like bone destruction (inflammatory erosions).

Paget's disease shows a high bone turnover with a sequence of events: osteoclasts resorb bone aggressively, and then osteoblasts lay down new bone rapidly. However, the remodeling is disorganized, producing a mosaic of woven and lamellar bone rather than a regular, well-ordered structure. This combination—excessive resorption followed by excessive, abnormal formation—gives bones that are enlarged and structurally weak.

This pattern is distinctive from simple osteoporosis (loss of bone mass), osteoarthritis (degenerative joint changes), or rheumatoid-arthritis–like bone destruction (inflammatory erosions).

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy