In osteoarthritis, which tissue is primarily affected?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

In osteoarthritis, which tissue is primarily affected?

Explanation:
Articular cartilage is the tissue primarily affected in osteoarthritis. The disease starts with breakdown of the cartilage matrix—loss of proteoglycans and type II collagen—due to mechanical wear and limited repair by chondrocytes in this avascular tissue. As cartilage thins and fibrillates, the joint loses its smooth, shock‑absorbing surface, leading to exposure and remodeling of the subchondral bone, sclerosis, cysts, and osteophyte formation. Synovial inflammation can occur, but it usually arises secondary to cartilage debris and ongoing joint damage rather than being the initial target of OA.

Articular cartilage is the tissue primarily affected in osteoarthritis. The disease starts with breakdown of the cartilage matrix—loss of proteoglycans and type II collagen—due to mechanical wear and limited repair by chondrocytes in this avascular tissue. As cartilage thins and fibrillates, the joint loses its smooth, shock‑absorbing surface, leading to exposure and remodeling of the subchondral bone, sclerosis, cysts, and osteophyte formation. Synovial inflammation can occur, but it usually arises secondary to cartilage debris and ongoing joint damage rather than being the initial target of OA.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy