In myositis, Anti-SRP is associated with which prognosis?

• A. Excellent
• B. Poor
• C. Unknown
• D. Moderate

Answer: (B)

Antibody profiles in inflammatory myopathies help predict how the disease will behave. Anti-SRP identifies a necrotizing autoimmune myopathy phenotype that is typically more aggressive. Patients often develop rapid, severe proximal weakness with very high CK levels and frequently show a poorer response to standard high-dose steroids, which pushes clinicians to use more intensive or combination immunosuppressive therapies. Because of the greater muscle injury and treatment resistance, the overall outlook tends to be worse than with other myositis-associated antibodies. Some may respond to therapies like IVIG or other agents, but anti-SRP generally signals a less favorable prognosis rather than an excellent or unknown or moderate one.