Anti-Jo-1 antibodies are associated with which of the following?

• A. Interstitial lung disease with inflammatory myopathy
• B. Renal failure
• C. Osteoarthritis
• D. Gout

Answer: (A)

Anti-Jo-1 antibodies are part of the antisynthetase group seen in antisynthetase syndrome, which links inflammatory myopathy with interstitial lung disease. They target histidyl-tRNA synthetase, and their presence often accompanies proximal muscle weakness with elevated muscle enzymes, along with interstitial lung disease. Patients may also have arthritis or skin changes such as mechanic’s hands, fever, or Raynaud’s. This combination—interstitial lung disease occurring with inflammatory myopathy—is the hallmark association, while renal failure, osteoarthritis, and gout do not fit this autoimmune profile.