Anakinra is an inhibitor of which interleukin receptor?

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Prepare for the CMS II Rheumatology E1 Exam with our comprehensive quiz. Study using flashcards and multiple-choice questions, each with hints and explanations. Get ready for success!

Multiple Choice

Anakinra is an inhibitor of which interleukin receptor?

Explanation:
Anakinra is an interleukin-1 receptor antagonist. It works by binding to the IL-1 receptor type I (and its accessory protein) and blocking signaling from both IL-1α and IL-1β, which reduces the inflammatory cascade driven by this pathway. This mechanism distinguishes it from the other agents: abatacept inhibits T-cell activation by blocking CD28 costimulation; rituximab depletes B cells by targeting CD20; and tocilizumab blocks the IL-6 receptor.

Anakinra is an interleukin-1 receptor antagonist. It works by binding to the IL-1 receptor type I (and its accessory protein) and blocking signaling from both IL-1α and IL-1β, which reduces the inflammatory cascade driven by this pathway. This mechanism distinguishes it from the other agents: abatacept inhibits T-cell activation by blocking CD28 costimulation; rituximab depletes B cells by targeting CD20; and tocilizumab blocks the IL-6 receptor.

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